for his work on ribonucleaseandfor their contribution to the understanding of the connection between chemical structure and catalytic activity of the ribonuclease molecule
for their elucidation of the enzymatic mechanism underlying the synthesis of adenosine triphosphateandfor his discovery of an ion-transporting enzyme, Na+, K+ -ATPase
... 1556 Charles abdicated his various positions, giving his personal empire to his son, Philip II of Spain, and the Holy Roman Empire to his brother, Ferdinand. Charles retired ...