1054, the Great Schism, in which the Western (Roman Catholic) and Eastern Orthodox churches separated from each other. After a number of earlier such schisms, the breach was later repaired, but this one continues nearly 1000 years later.
... coast posed a threat to Hapsburg lands and the peace of Western Europe. In 1535 Charles won an important victory at Tunis, but in 1536 Francis I of Spain allied ...