After the 10th shogun Ashikaga Yoshitane and Hosokawa Takakuni[?] struggled for power over the shogunate in 1521, Yoshitane ran away to Awaji island[?] and Yoshiharu was installed as a puppet shogun. Not having any political power and repeatedy being forced out of the capital of Kyoto, Yoshiharu eventually retired in 1546 over a politic struggle between Miyoshi Nagayoshi[?] and Hosokawa Harumoto[?] making his son Ashikaga Yoshiteru the 13th shogun.
Supported by Oda Nobunaga, his son Ashikaga Yoshiaki became the 15th shogun.
From a western perspective, Yoshiharu is significant, as he was shogun in 1542, when the first contact of Japan with the European West when a Portuguese ship, blown off its course to China, landed in Japan.
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