Encyclopedia > Trimethoprim

  Article Content

Trimethoprim

Trimethoprim is a bactericidal antibiotic which acts by interfering with the action of bacterial dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. It is most commonly used in combination with sulfamethoxazole, which inhibits the formation of folic acid from para-aminobenzoic acid[?] (PABA). The two drugs, given orally or intravenously in a fixed ratio, are manufactured under the trade-names Bactrim, Septra, Cotrim, or in generic formulation, and act synergistically by inhibiting successive steps in folate metabolism.

The medication is commonly used in urinary tract infections and in pneumocystis carinii pneumonia.


Further information
Nucleic Acid Inhibitors
http://www.med.sc.edu:96/Biopharm/PDFs/NucleicAcidInhibitors.pdf



All Wikipedia text is available under the terms of the GNU Free Documentation License

 
  Search Encyclopedia

Search over one million articles, find something about almost anything!
 
 
  
  Featured Article
242

... century Decades: 190s 200s 210s 220s 230s - 240s - 250s 260s 270s 280s 290s Years: 237 238 239 240 241 - 242 - 243 244 245 246 247 Events Patriarch Titus[?] ...

 
 
 
This page was created in 24.6 ms