Trimethoprim is a bactericidal antibiotic which acts by interfering with the action of bacterial dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. It is most commonly used in combination with sulfamethoxazole, which inhibits the formation of folic acid from para-aminobenzoic acid[?] (PABA). The two drugs, given orally or intravenously in a fixed ratio, are manufactured under the trade-names Bactrim, Septra, Cotrim, or in generic formulation, and act synergistically by inhibiting successive steps in folate metabolism.
... the then prince-regent Dom Pedro I established the independent Empire of Brazil. This lasted until the next emperor, Dom Pedro II was deposed in 1889 and a republican ...