Encyclopedia > Dihydrofolate reductase

  Article Content

Dihydrofolate reductase

Dihydrofolate reductase (PDB 7DFR (http://www.rcsb.org/pdb/cgi/explore.cgi?pid=117351033147076&pdbId=7DFR), EC 1.5.1.3), or DHFR, reduces dihydrofolic acid to tetrahydrofolic acid, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry.

A variety of drugs act on dihydrofolate reductase, including the antibiotic trimethoprim, the antimalarial drug pyrimethamine[?], and the chemotheraputic agent methotrexate[?]. The first anticancer drug, aminopterin[?], also acts on this enzyme, binding some 1000 times more tightly to the enzyme than folate itself.

DHFR is the Protein Data Bank's molecule of the month for October 2002.


Further information
1988 Nobel Lecture in Medicine
http://www.nobel.se/medicine/laureates/1988/hitchings-lecture.pdf



All Wikipedia text is available under the terms of the GNU Free Documentation License

 
  Search Encyclopedia

Search over one million articles, find something about almost anything!
 
 
  
  Featured Article
BBC News 24

... in promoting the take-up of digital television. BBC News 24 broadcasts from the BBC News Centre in BBC Television Centre, West London. See also: List of British ...

 
 
 
This page was created in 24.2 ms