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Sertraline hydrochloride ((1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-nanphthalenamine hydrochloride, C17H17NCl2HCl) is a white, sparingly soluble crystalline solid.

Sertraline is used medically to treat the symptoms of depression. It is a selective serotonin reuptake inhibitors and works by blocking the uptake of serotonin into platelets. It is prescribed under the tradename Zoloft and is manufactured by Pfizer, as white and yellow 50 mg capsules or orange 100 mg capsules. It is used in dosages of between 50 mg and a maximum of 200 mg per day. It has also been prescribed for the treatment of obsessive-compulsive disorder, post-traumatic stress disorder, premenstrual dysphoric mood disorder[?] and panic disorder[?]. It was first approved by the FDA in 1997.

It has a number of adverse effects including insomnia, asthenia, gastrintestinal complaints, tremours, confusion and dizziness, it can induce mania or hypomania in around 0.5% of patients. It is contraindicated in individuals taking MAOIs or undergoing electroconvulsive therapy.

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