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On his second missionary journey, Paul preached in the synagogue here, the chief synagogue of the Jews in that part of Macedonia, and laid the foundations of a church. Opposition against him from the Jews drove him from the city, and he fled to Berea[?].
From its capture from Macedonia, Thessaloniki was part of the Roman Empire until Constantinople was captured by the Fourth Crusade in 1204. The city was recovered in 1246, but unable to hold it against the encroachments of the Ottoman Empire, the Byzantine Despot Andronikos Palaeologus[?] was forced to sell it to Venice, who held it until 1430.
Under the rule of the Ottoman Empire until 1912, Thessaloniki became noted for its large Jewish population of Sephardic origin, the result mostly of Spain's expulsion of Jews after 1492 (few Romaniotes Jews where also included). Many of the city's Jews were killed during the German occupation of 1941-1944.
Thessaloniki was the theater of the two Balkan wars (1913) before being finally incorporated by Greece. During World War I a temporary government headed by Eleutherios Benizelos[?] was established there taking the side of the British-French allies, against the will of the pro-neutral German King of Greece.