It was designed by two Dominican friars, Fra Sisto da Firenze and Fra Ristoro da Campi. On a commission from the Rucellai family Leone Battista Alberti designed the black and white marble facade of the church (1456-1470). Giorgio Vasari was the architect for the first remodelling of the church, which included removing its original rood-screen and loft. The second remodelling was designed by Enrico Romoli, and was carried out between 1858 and 1860.
The interior is designed as a Latin cross and is divided up into three naves. The centre nave is 100 metres long. The chapels include the della Pura Chapel, the Rucellai Chapel, the Bardi Chapel, the Filippo Strozzi Chapel, and the Gondi Chapel.
Artists who produced items for the church include:
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