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Rational drug design

Unlike the historical method of drug design[?], by trial-and-error testing of chemical substances on animals, and matching the apparent effects to treatments, rational drug design begins with a knowledge of specific chemical responses in the body, and tailoring combinations of these to fit a treatment profile.

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Thomas a Kempis

... preserved in Cologne. The editions in German began at Augsburg in 1486. The first English translation (1502) was by William Atkinson and Margaret, mother of Henry VII., ...