Proton pump inhibitor

Proton pump inhibitors is a group of drugs whose main action is pronounced and long-lasting reduction of gastric acid[?] production. The group followed another group of pharmaceuticals with similar action called H₂ antagonists[?]. Proton pump inhibitors act by by blocking the hydrogen-potassium adenosine triphosphatase[?] enzyme system (the so called proton pump ) of the gastric parietal cell[?]. Hence the enzyme inhibited is the terminal stage in gastric acid production. These drugs are utilized in treatment of :

• duodenal and peptic ulcers
• Zollinger-Ellison syndrome[?]
• and erosive reflux oesophagitis.

Examples :

• omeprazole[?]
• lansoprazole[?]
• esomeprazole[?]
• pantoprazole[?]
• rabeprazole[?]