Both I and O are capitalized when used.
The word E is the shortest English neologism and is a Spivak pronoun meaning he or she. It is also a common abbreviation for the drug Ecstasy.
e is a mathematical and scientific constant, referring to the base of the natural logarithm.
In gangster rap culture, G is a valid word, a contraction of "gangster", used as a term of respect.
There are also various single letter words used as abbreviations in text-speak and related uses:
Various digits have also been pressed into service in this manner:
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