In lipid anchored proteins a covalently attached
fatty acid such as palmitate or myristate serves to anchor them to the
cytoplasmic face of the
cell membrane. Examples include
G proteins and certain
kinases. It is believed that the fatty-acid chain inserts and assumes a place in the
bilayer structure of the membrane alongside the similar fatty-acid tails of the surrounding
lipid molecules. Potential points of attachment include the terminal amino group of the
protein backbone and the side chain of
cysteine residues.
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