The usual periodization practiced by modern historians is to see the death of Alexander the Great in 323 BC as dividing the Hellenic period from the Hellenistic. Alexander and the Macedonians conquered the eastern Mediterranean, Mesopotamia, and the Iranian plateau[?], and invaded India; his successors held on to the territory west of the Tigris for some time and controlled the eastern Mediterranean until the Roman Republic took control in the 2nd and 1st centuries B.C. Most of the east was eventually overrun by the Parthians
Following the death of Alexander, there was a struggle for the succession, kown as the wars of the Diadochi[?] (Greek, successors), which ended in 281 BC resulting in the establishment of three large territorial states:
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