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Halotolerance is the adaptation of living organisms to conditions of high salinity. Halotolerant species tend to live in areas such as coastal dunes, saline deserts[?], salt marshes, and inland salt seas and springs. Halophiles are a group of bacteria that live in highly saline environments, and indeed in many cases require the salinity to survive. Halophytes are salt-tolerant higher plants.

Fields of scientific relearch relevant to halotolerance include biochemistry, molecular biology, cell biology, physiology, ecology, and genetics.

An understanding of halotolerance can be applicable to areas such as arid-zone agriculture, xeriscaping, aquaculture (of fish or algae), bioproduction of desirable compounds (such as phycobilins[?] or carotenoids[?]) using seawater to support growth, or remediation[?] of salt-affected soils. In addition, many environmental stressors involve or induce osmotic changes, so knowledge gained about halotolerance can also be relevant to understanding tolerance to extremes in moisture or temperature.

Goals of studying halotolerance include increasing the agricultural productivity of lands affected by soil salination or where only saline water is available. Conventional agricultural species could be made more halotolerant by gene transfer from naturally halotolerant species (by conventional breeding[?] or genetic engineering) or by applying treatments developed from an understanding of the mechanisms of halotolerance. In addition, naturally halotolerant plants or microorganisms could be developed into useful agricultural crops or fermentation organisms.

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