GRK3

In 2003, a group of American and Canadian researchers published a paper that used gene linkage[?] techniques to identify a mutation in the GRK3 gene as a possible cause of up to 10% of cases of bipolar disorder. This gene is associated with a kinase enzyme called G protein receptor kinase 3[?], which appears to be involved in dopamine metabolism, and may provide a possible target for new drugs for bipolar disorder.

this is a stub article

To do: which chromosome, what pathways, explain the biology a bit

References:

• T B Barrett, R L Hauger, J L Kennedy, A D Sadovnick, R A Remick, P E Keck, S L McElroy, M Alexander, S H Shaw, and J R Kelsoe, "Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder", in Molecular Psychiatry, 2003, Volume 8, Number 5, Pages 546-557.

External link

• online version of the paper in Molecular Psychiatry (http://www.nature.com/cgi-taf/DynaPage.taf?file=/mp/journal/v8/n5/abs/4001268a&dynoptions=doi1056040331)
• PubMed abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12808434&dopt=Abstract)
• http://www.sciencedaily.com/releases/2003/06/030617080403.htm