Talk:Glycolysis

Data dump: Key
1) Chimical diagram of reactants

2) Names of reactants
(reaction type & enzyme) δ G°' = ?
*critical control point

Glycolysis 1 ATP -> ADP + H+ 1) . = radioactive label

    H<sub>2</sub>COH             H<sub>2</sub>OCPO<sub>3</sub><sup>-2</sup>
      |___O              |___O
    ./     \    -->    ./     \
    |\|___ /|  <--–    |\|___ /|
          |                  |
     + ATP              + ADP + H+

2) å-D-G ––---> å-D-G-6-P
(phosphorylation, *Hexokinase)
-4.0 kcal/mol ATP -> ADP + H⁺

Glycolysis 2

1) (P) is H₂COPOsub>3</sub>^-2

         H2COPO3-2    
           |___O          (P) O   CH2OH
         ./     \    -->   |/    \|
         |\|___ /|  <--–––  \.__|/|
               |             |

2) å-D-G-6-P ––--> Fructose-6-P
(isomeration, phosphoglucoisomerase)
+0.4 kcal/mol

Glycolysis 3
ATP -> ADP + H+
1) (P) is H₂COPO₃⁺

   
      (P)  O   CH2OH         (P)  O  (P)
       |/     \|     -->      |/    \|
        \.__ |/|     <--–––    \.__|/|
         |                      |

         + ATP   + ADP + H+ 

2) F-6-P --> F-1,6-BP
(phoshorylation, phosphofrucoknse)
-3.4 kcal/mol ATP -> ADP + H⁺

Glycolysis 4
1) (P)

      |             (P)       HC.=O
      C=O            |         |
   __ |  –––  -->    C=O    + HCOH
      |.__   <--–––  |         |
      | __         H2C.OH     (P)
      |  
     (P)

2) F-1,6-BP --> DHAP + Gy-3-P
(Isomerization, *aldolase)
+5.7 kcal/mol

DHAP Dihydroxyacetone Phosphate

Glycolysis 5
1) Lable is mixed in 2 species

      (P)          HC.=O
       |            |
       C=O   -->   HCOH
       |     <--    |
     H2C.OH        (P)
       98%          2%

2) DHAP --> Gy-3-P
(isomerization, triose-phosphate isomerase)
+1.83 kcal/mol

Glycolysis 6
2(NAD -> NADH)
1) Double all molecules

        HC.=O          O=C.-OPO3-2
         |       -->     |
        HCOH    <--––   HCOH
         |               |
        (P)             (P)

     + NAD + Pi     + NADH + H+

2) 2(Gy-3-P --> 1,3-BP-Gy)
(dehydration, Gy-3-P dehydrogenase)
+1.5 kcal/mol NAD + Pi -> NADH

Glycolysis 7
2(ADP -> ATP)
1) Double all molecules

        O=C.-OPO3-2 C.OO-
          |         |
         HCOH  --> HCOH
          |    <--  |   
         (P)       (P)

        + ADP     + ATP

2) 2(1,3-BP-Gy --> 3-PGy)
(Phosphoryl Transfer, phosphoglycerate kinase)
-4.5 kcal/mol 2(ADP -> ATP)

Glycolysis 8
1) Double all molecules

          C.OO-       C.OO-
          |      -->  |
         HCOH   <--  (P)
          |           |   
         (P)        H2COH

                    Note 

2) 2(3-PGy --> 2-PGy)
(Phosphoryl Shift, phosphoglyceromutase)
+1.06 kcal/mol
Note: 2-PGy's (P) has 1 fewer H than referance (P).

Glycolysis 9

  ---> + 2H2O

        C.OO-        C.OO-
        |  –   -->   |
       (P)    <--   (P)
        |           ||   
       H2COH         CH2

       Note         + H2O

2) 2(2-P-Gy ----> phosphoenol Py)
(Dehydration, enolase)
1st molecule's (P) has 1 fewer H than referance (P).
2nd molecule's (P) has 2 fewer H than normal (P)

Glycolysis 10
2(ADP -> ATP)
1) Double all molecules (Note 1)

       C.OO-         C.OO-
       |  –    -->   |
      (P)     <--–   C=O
      ||             |   
      CH2            CH3

     + ADP          + ATP

2) 2(PEP --> pyruvate)
(Phosphoryl Transfer, ) ADP -> ATP
-7.5 kcal/mol
Note: 1st molecule's (P) has 2 fewer H than normal (P)

TODO: Double check to make sure this is correct, try to translate into English, put into right justified table with text of article flowing on the left. --maveric149