The leaguer of the Noldor around the fortress of Morgoth in the early centuries of the First Age. The Siege was broken in the Dagor Bragollach.
... Weyers type[?] Acrofacial dysostosis, Nager type[?] Acrofacial dysostosis, Palagonia type[?] Acrokeratoelastoidosis of Costa[?] Acromegaloid changes cutis ...