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Sharpless bishydroxylation

Sharpless bishydroxylation is a chemical reaction of an alkene with osmium tetroxide to form an diol (dialcohol). Chiral products can be formed by adding quinine derivatives. A more efficient way to perform this reaction is reoxidise the osmate, which is formed in the reaction, with potassium hexacyanoferrate[?]. This reduces the amount of the highly toxic and very expensive osmium tetroxide needed by up to 95%. It is possible to buy these mixtures as AD-mix α and AD-mix β.

The chiral diols are important for further synthesis. The introduction of chirality into nonchiral reactants through small amounts of a chiral catalyst is an important concept in organic synthesis[?].

K. Barry Sharpless[?] won the 2001 Nobel Prize in Chemistry.



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