Encyclopedia > Sharpless bishydroxylation

  Article Content

Sharpless bishydroxylation

Sharpless bishydroxylation is a chemical reaction of an alkene with osmium tetroxide to form an diol (dialcohol). Chiral products can be formed by adding quinine derivatives. A more efficient way to perform this reaction is reoxidise the osmate, which is formed in the reaction, with potassium hexacyanoferrate[?]. This reduces the amount of the highly toxic and very expensive osmium tetroxide needed by up to 95%. It is possible to buy these mixtures as AD-mix α and AD-mix β.

The chiral diols are important for further synthesis. The introduction of chirality into nonchiral reactants through small amounts of a chiral catalyst is an important concept in organic synthesis[?].

K. Barry Sharpless[?] won the 2001 Nobel Prize in Chemistry.

All Wikipedia text is available under the terms of the GNU Free Documentation License

  Search Encyclopedia

Search over one million articles, find something about almost anything!
  Featured Article
Great River, New York

... and 17.9% are non-families. 13.4% of all households are made up of individuals and 5.5% have someone living alone who is 65 years of age or older. The averag ...

This page was created in 36.7 ms