SH3 domains have a consensus sequence[?]:
-X-P-p-X-P- 1 2 3 4 5with 1 and 4 being aliphatic[?] amino acids, 2 and 5 always and 3 sometimes being proline. The sequence binds to the hydrophobic pocket of the SH3 domain.
SH3 domains are often found in functions concerning the cytoskeleton, the ras protein[?], and the src kinase[?]. They also increase the substrate specificity of tyrosine kinases by binding far away from the catalytic center[?] of the kinase.
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