Gnaeus Pompeius Magnus (born Rome, 106 B.C., died September 28, 48 B.C.) known in the English-speaking world as Pompey the Great, was a leading general of the late Roman Republic and chief rival to Julius Caesar, although they served together in the First Triumvirate.
... married infanta Isabella, sister of John III of Portugal, who had shortly before married Catherine, Charles's sister.
Charles V initiated many wars with France ...