The term originated in literary works in the 19th century to depict the dangers of science.
In recent years it has been used whimsically by popular science writers to attract readers (things are more interesting if they are somehow dangerous).
Mad scientists are typically characterized by obsessive behaviour and the employment of extremely dangerous methods. The general rule to follow when you encounter mad scientist experiments is 'do not attempt this at home!'
characterizations:
example mad scientists in fiction:
real-life prototypes:
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