A lunatic (colloquially, "loony") is a person who is mentally ill, traditionally someone whose sanity comes and goes with the phases of the Moon.
This probably refers to the symptoms of what is now known as Bipolar disorder.
Extremely foolish persons are also called lunatics.
... sister.
Charles V initiated many wars with France during his reign, first fighting against them in Northern Italy in 1521. Later, in 1527, his troops sacked Rome, ...