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Kleenex is a brand name of facial tissue paper and a registered trademark of the Kimberly-Clark Corporation. Because of the success of this brand, many people today refer to any tissue as a "Kleenex", but Kleenex remains a trademark legally referring only to the product of Kimberly-Clark.

The material from which Kleenex is made was originally called "Cellucotton," and was designed by Kimberly-Clark during World War I. It came to be used in gas mask filters during the war, as a replacement for cotton, which was in high demand for use as a surgical dressing.

Kimberly-Clark created the first facial tissue in 1924, and later introduced paper towels, and paper napkins. These facial tissues were originally marketed as a cleaning tissue for such usages as removing cold cream[?]. Later they were marketed as a disposable paper tissue. In the 1930s, the Kimberly-Clark Corporation received a large amount of letters from customers suggesting its use for colds and hay fever[?]. Kleenex were first advertised for use as a handkerchief[?] replacement in 1926; this was to become the product's dominant use. Early advertising recommended using disposable Kleenex instead of a handkerchief with the slogan "Don't Carry A Cold In Your Pocket".

Kleenex is now manufactured in 19 countries, and sold in 150 countries.

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