is an 31 kd protein
produced from the the C-terminal portion of the Pol gene product. The integrase protein contains three domains: an N-terminal HH-CC zinc finger
domain believed to be partially responsible for multimerization, a central catalytic domain and an C-terminal DNA
binding domain. Integrase is responsible for the integration of proviral DNA into the host genome, which is essential for HIV replication. Integrase, therefore, remains a promising potential target for new anti-HIV therapeutics.
See also: retrovirus
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