Encyclopedia > Integrase

  Article Content


HIV integrase is an 31 kd protein produced from the the C-terminal portion of the Pol gene product. The integrase protein contains three domains: an N-terminal HH-CC zinc finger domain believed to be partially responsible for multimerization, a central catalytic domain and an C-terminal DNA binding domain. Integrase is responsible for the integration of proviral DNA into the host genome, which is essential for HIV replication. Integrase, therefore, remains a promising potential target for new anti-HIV therapeutics.

See also: retrovirus

All Wikipedia text is available under the terms of the GNU Free Documentation License

  Search Encyclopedia

Search over one million articles, find something about almost anything!
  Featured Article

... a "Second Manifesto" against polygamy Art, Culture & Fashion 1904 in film The Great Train Robbery, by Siegmund Lubin[?] (a remake of the 1903 classic...) The giant ...

This page was created in 21.7 ms