Encyclopedia > Integrase

  Article Content

Integrase

HIV integrase is an 31 kd protein produced from the the C-terminal portion of the Pol gene product. The integrase protein contains three domains: an N-terminal HH-CC zinc finger domain believed to be partially responsible for multimerization, a central catalytic domain and an C-terminal DNA binding domain. Integrase is responsible for the integration of proviral DNA into the host genome, which is essential for HIV replication. Integrase, therefore, remains a promising potential target for new anti-HIV therapeutics.

See also: retrovirus



All Wikipedia text is available under the terms of the GNU Free Documentation License

 
  Search Encyclopedia

Search over one million articles, find something about almost anything!
 
 
  
  Featured Article
1904

... historian July 14 - Anton Chekhov, Russian playwright and short story writer July 22 - Wilson Barrett, actor August 22 - Kate Chopin, author August 25 - Henri ...

 
 
 
This page was created in 26.6 ms