Glycome

The glycome may in fact be one of the most complex entities in nature.

The Genome is one of the most complex structures in an organism (althoough not necessarily as complex as, for example, the brains of higher organisms).

The genome is responsible for the Proteome, which is more complex that the genome by virtue of the fact that it combines the complexity of the genome with the complexity of the proteins which the genome specifies, proteins whose characteristics are at least partially determined by the phenomenon of molecular folding, which is one of the most complex phenomena known to science.

The glycome exceeds the complexity of the proteome as a result of the even greater diversity of the glycome's constituent carbohydrates and is further complicated by the sheer multiplicity of their possibilities of combination and interaction of the carbohydrates with each other and with proteins.

An alternative definition is the collective identity of the entirety of carbohydrates in a cell.

In those definitions, the word sugar, the word glycan and the word polysaccharide can be meaningfully substituted for carbohydrate.

The following article discusses the possibility of a 'Human Glycome Project[?]'.

The article, called Glycobiology Goes to the Ball (http://www.glycominds.com/theScientist.asp?HighLight=News) by Jeffrey M. Perkel, appeared in The Scientist on April the 29th 2002.

A classic quote from this article (given by Ajit Varki, professor of medicine and cell and molecular biology, and director of the Glycobiology Research and Training Center at the University of California, San Diego (http://grtc.ucsd.edu/)) which illustrates the scale of the glycome challenge, is that the glycome is:

"...probably thousands of times as complicated as the genome, in magnitude of complexity and level of diversity".

There is a pivotal body in this field, called the Consortium for Functional Glycomics (CFG) funded by the (US) National Institute of General Medical Sciences (http://www.nigms.nih.gov/).

This body (which operates in a field called Glycosciences[?]) includes participants in 'glycome projects' within its remit.

The US Federal grant which can be said to have 'put the glycome on the political map' was described as a 'glue grant' of $34M (for the formation of the CFG, see above) described in this article (http://ucsdnews.ucsd.edu/newsrel/health/gluegrant.htm) from the 9th of October 2001.

An article, primarily aimed at discussing the technological aspects of the glycome challenge is 'The Sweet Spot' (http://www.bio-itworld.com/archive/121002/israel_sidebar_1640) which talks about Glycominds (http://www.glycominds.com/) who are founding commercial co-sponsors of the CFG.

Other terms which describe this field include glycomics, glycobiology.

Periodicals covering glycome projects

Bio-IT World (http://www.bio-itworld.com/)

Glycome issues

• Genomics

• Proteomics

• cellular adhesion

• cellular communication

• 'GlycoChip' (http://www.glycochip.com/)

Articles on the glycome

The Sugar Rush (http://glycomics.scripps.edu/sugarrush.pdf) Adobe Acrobat PDF

The Glycome Project: A Sugar Coated Proposal (http://gnn.tigr.org/articles/05_01/Glycome_project.shtml)

A proposal to base the glycome project on Caenorhabditis Elegans a microscopic worm, whose entire genome is already sequenced:

Glycome project: concept, strategy and preliminary application to Caenorhabditis elegans (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11680876&dopt=Abstract)