Holyoke was also a founder of the American Academy of Arts and Sciences[?], of which he was president from 1814 to 1820. Coincidently, he was also a founder and president of the Massachusetts Medical Society from 1782-1784 and 1786-1788[?]. His length of service to the medical practice and to his pioneering work in the advancement of smallpox vaccinations aren't overlooked.
His death at age 100 in 1829 (quite a lifespan for that time) was not only incredible, but amazing, considering that life expectancy was only to 50.
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