One of the motivations for this work is the observation of high-energy cosmic rays that appear to violate the Greisen-Zatsepin-Kuzmin limit: the so-called GZK paradox.
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... ataxia cataract aminoaciduria mental retardation[?] Arachnodactyly mental retardation dysmorphism[?] Arachnoid cysts[?] Arachnoiditis[?] Arakawa'sa syndrome ...