Encyclopedia > Chymotrypsin

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Chymotrypsin (bovine γ chymotrypsin: PDB 1AB9 (http://www.rcsb.org/pdb/cgi/explore.cgi?pid=217921034360664&page=0&pdbId=1AB9), EC is a digestive enzyme that can perform proteolysis.

Activation of chymotrypsin Chymotrypsin is synthesized by protein biosynthesis as a precursor[?] called chymotrypsinogen that is enzymatically inactive. On cleavage by trypsin into two parts that are still connected via an S-S bond, cleaved chymotrypsinogen molecules can activate each other by removing two small peptides in a trans-proteolysis. The resulting molecule is chymotrypsin, three polypeptides interconnected via S-S bonds.

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