Children of Dune

Warning: Wikipedia contains spoilers

Paul Atreides had two children, Leto and Ghanima. At the end of Dune Messiah, Paul walked into the desert, a blind man, leaving the children in the care of the Fremen while their aunt Alia rules the universe as regent. Awoken in the womb by the spice, the children are the heirs to Paul's prescient vision of the fate of the universe, a role that Alia desperately craves. House Corrino, the previous imperial house, schemes to return to the throne, while the Bene Gesserit make common cause with the Bene Tleilaxu to destroy all three "abominations".

The series:

• Dune
• Dune Messiah
• Children of Dune
• God Emperor of Dune
• Heretics of Dune
• Chapterhouse Dune