The disease begins with a small pustule at the site of the scratch, and painful swelling of the local lymph nodes follows. In more severe cases there may be fever, malaise[?] and anorexia. The disease usually resolves spontaneously, with or without treatment, in one month. In immunocompromised patients more severe complications sometimes occur.
The causative organism was first thought to be Afipia felis, but this was disproven by immunological studies demonstrating that cat scratch fever patients developed antibodies to another organism, called at the time Bartonella henselae but now reclassified as Rochalimaea henselae. It is a rod-shaped Gram negative organism.
Kittens are more likely to carry the bacteria in their blood, and are therefore more likely to transmit the disease than are adult cats.
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