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Cardiomyopathy

Cardiomyopathy is the death and deterioration of the cardiac muscle[?] of the heart wall.

It has a number of causes including drug and alcohol toxicity, certain infections, and various genetic and idiopathic[?] causes. It can lead to heart failure by ...?

Hypertrophic cardiomyopathy (HCM) is a genetic disorder caused by various mutations in 10 genes encoding sarcomeric proteins. However, these mutations only partially account for the variability in left ventricular hypertrophy (LVH) and other phenotypic features of the disease. It has been suggested that in patients with HCM, the final phenotype, including LVH, is the product of the causal mutation in genes encoding sarcomeric proteins, modifier genes and environmental factors.



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... iron centre of the heme group attached to the enzyme.) As hydrogen peroxide enters the active site it is forced to interact with the amino acids His74 and Asn174. This ...