Beta-lactamase

Beta-lactamase is a type of enzyme responsible for bacterial resistance to penicillin-type antibiotics. Penicillin and related antibiotics have a common element in their molecular structure, a four-atom ring known as a beta lactam (See ampicillin for an example of a penicillin structure). The lactamase enzyme breaks that ring down, rendering the molecule inactive as an antibiotic.

The structure of a Streptomyces[?] β lactamase is given by PDB 1BSG (http://www.rcsb.org/pdb/cgi/explore.cgi?pid=149261034357864&page=0&pdbId=1BSG) EC 3.5.2.6)