The 
AP-101 is the computer used in the U.S. space shuttle.  When it was designed, it was a high-performance pipelined processor with core memory.  In 2003, its specifications are exceeded by many 
microprocessors.  It is primarily programmed in 
JOVIAL.
Further reading
The new AP101S General-Purpose Computer (GPC) for the Space Shuttle, 
Norman, P. Glenn (IBM Corp.), IEEE Proceedings, Volume 75, Page 308-319,
Mar 01, 1987
 
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